Title : Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.

Pub. Date : 2010 Jan

PMID : 19919601






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens