Pub. Date : 2009 Nov
PMID : 19916996
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 2 | Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 3 | Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 4 | Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 5 | AIMS: Although in vitro studies indicate that oxazepam is an isoform-selective substrate probe for UDP-glucuronosyltransferase 2B15, the utility of this drug as an in vivo probe is uncertain. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 6 | The main aim of this study was to determine whether common missense polymorphisms in the UGT2B15 gene (D85Y and K523T) are associated with altered oxazepam pharmacokinetics and pharmacodynamics. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 7 | CONCLUSIONS: These results identify UGT2B15 D85Y as a major determinant of oxazepam clearance, and indicate that oxazepam may be useful as an in vivo probe for glucuronidation by UGT2B15. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 8 | CONCLUSIONS: These results identify UGT2B15 D85Y as a major determinant of oxazepam clearance, and indicate that oxazepam may be useful as an in vivo probe for glucuronidation by UGT2B15. | Oxazepam | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |