Title : Chemopreventive actions by enterolactone and 13 VIOXX-related lactone derivatives in H295R human adrenocortical carcinoma cells.

Pub. Date : 2010 Feb 15

PMID : 19913079






1 Functional Relationships(s)
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1 Of the VIOXX-related lactone derivatives, CRI-7 could prove useful in the prevention of hormone-dependent cancers, such as breast cancer, since in vitro it shows low cytotoxicity, it is a potent inhibitor of CYP17 activity and strong inducer of cell cycle arrest. Lactones cytochrome P450 family 17 subfamily A member 1 Homo sapiens