Title : Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.

Pub. Date : 2009 Nov 13

PMID : 19912636






5 Functional Relationships(s)
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1 BACKGROUND: We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
2 BACKGROUND: We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
3 LPC-induced LPA production was markedly diminished in ATX heterozygotes, and was abolished in mice that were deficient in LPA3, but not LPA1 or LPA2 receptors. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
4 In an in vitro study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA3 receptor. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
5 In an in vitro study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA3 receptor. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus