Title : 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin.

Pub. Date : 2010 Mar

PMID : 19909832






5 Functional Relationships(s)
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1 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Glucosamine ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
2 We determined the effect of glucosamine on ADAMTS5 (a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type-1 motifs 5), a major aggrecanase in osteoarthritis, and investigated a potential mechanism underlying the observed effects. Glucosamine ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
3 RESULTS: Ten mM glucosamine and 5-10mM mannosamine reduced excision of the ADAMTS5 propeptide, indicating interference with the propeptide excision mechanism, although mannosamine compromised cell viability at these doses. Glucosamine ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
4 CONCLUSIONS: Ten mM glucosamine reduces excision of the ADAMTS5 propeptide via interference with post-translational modification of furin and leads to reduced aggrecanase activity of ADAMTS5. Glucosamine ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
5 CONCLUSIONS: Ten mM glucosamine reduces excision of the ADAMTS5 propeptide via interference with post-translational modification of furin and leads to reduced aggrecanase activity of ADAMTS5. Glucosamine ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens