Title : Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.

Pub. Date : 2010 Jan 14

PMID : 19908836






1 Functional Relationships(s)
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1 Optimization of a screening hit using structure-based design and modification of log D and chemical structural features led to the identification of a class of orally bioavailable non-quinone-containing Hsp90 inhibitors. quinone heat shock protein 90 alpha family class A member 1 Homo sapiens