Title : Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.

Pub. Date : 2010 Jul 15

PMID : 19908231






2 Functional Relationships(s)
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1 Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF. Resveratrol mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 As compared to vehicle control, resveratrol also suppressed the NF-kappaB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin. Resveratrol mitochondrially encoded cytochrome c oxidase II Homo sapiens