Pub. Date : 2010
PMID : 19907186
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells. | Histamine | interleukin 6 | Homo sapiens |
| 2 | Histamine stimulation significantly increased concentrations of IL-6 in conditioned medium, as did tumor necrosis factor-alpha and IL-1beta in positive controls. | Histamine | interleukin 6 | Homo sapiens |
| 3 | In addition, the H1R antagonist olopatadine significantly blocked histamine-induced production of IL-6, whereas the H2R antagonist ranitidine did not. | Histamine | interleukin 6 | Homo sapiens |
| 4 | CONCLUSION: Histamine appears to induce IL-6 production through H1R in human amnion cells. | Histamine | interleukin 6 | Homo sapiens |