Title : Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.

Pub. Date : 2010 Feb

PMID : 19906781






1 Functional Relationships(s)
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1 In human umbilical vein endothelial cells, L-165041 and GW0742 increased nitric oxide (NO) production and Akt and endothelial NOS (eNOS) phosphorylation, which were sensitive to PI3K inhibition and PPAR-beta blockade. GW0742 AKT serine/threonine kinase 1 Homo sapiens