Pub. Date : 2009 Dec
PMID : 19903766
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine enhances the antiapoptotic function of Mcl-1 through phosphorylation. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Here, we found that nicotine induces Mcl-1 phosphorylation through activation of extracellular signal-regulated kinase 1/2 in association with increased chemoresistance of human lung cancer cells. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Since nicotine stimulates Mcl-1 phosphorylation and survival in cells expressing wild-type but has no such effects in cells expressing T163A Mcl-1 mutant, this indicates that nicotine induces Mcl-1 phosphorylation exclusively at the T163 site and that phosphorylation of Mcl-1 at T163 is required for nicotine-induced survival. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Mechanistically, nicotine-induced Mcl-1 phosphorylation significantly enhances the half-life of Mcl-1, which renders Mcl-1 a long-term survival activity. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 5 | Mechanistically, nicotine-induced Mcl-1 phosphorylation significantly enhances the half-life of Mcl-1, which renders Mcl-1 a long-term survival activity. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 6 | Mechanistically, nicotine-induced Mcl-1 phosphorylation significantly enhances the half-life of Mcl-1, which renders Mcl-1 a long-term survival activity. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 7 | Specific depletion of Mcl-1 by RNA interference blocks nicotine-stimulated survival and enhances apoptotic cell death. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 8 | Thus, nicotine-enhanced survival of lung cancer cells may occur through activation of Mcl-1 by phosphorylation at T163 site, which may contribute to development of human lung cancer and/or chemoresistance. | Nicotine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |