Pub. Date : 2010 Feb 10
PMID : 19903468
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells. | Diphosphonates | proline rich transmembrane protein 2 | Homo sapiens |
| 2 | Since protein kinase C (PKC) plays a crucial role in cancer progression, we examined the effect of bisphosphonates on PKC expression to clarify the mechanism behind the inhibition of the bone metastasis of prostate cancer by bisphosphonates. | Diphosphonates | proline rich transmembrane protein 2 | Homo sapiens |
| 3 | This is the first finding that bisphosphonates suppress PKC expression in cancer cells. | Diphosphonates | proline rich transmembrane protein 2 | Homo sapiens |
| 4 | These results strongly suggest that one of the mechanisms behind the inhibitory effect of bisphosphonates on tumor bone metastasis is mediated by PKC inhibition. | Diphosphonates | proline rich transmembrane protein 2 | Homo sapiens |