Pub. Date : 2010 Feb 10
PMID : 19903468
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Urokinase-type plasminogen activator (uPA) is one of the critical proteins in tumor metastasis and decreased in bisphosphonate-treated PC-3 cells. | Diphosphonates | plasminogen activator, urokinase | Homo sapiens |
| 2 | Urokinase-type plasminogen activator (uPA) is one of the critical proteins in tumor metastasis and decreased in bisphosphonate-treated PC-3 cells. | Diphosphonates | plasminogen activator, urokinase | Homo sapiens |
| 3 | We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition. | Diphosphonates | plasminogen activator, urokinase | Homo sapiens |
| 4 | We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition. | Diphosphonates | plasminogen activator, urokinase | Homo sapiens |