Title : Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.

Pub. Date : 2010 Feb 10

PMID : 19903468






4 Functional Relationships(s)
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1 Urokinase-type plasminogen activator (uPA) is one of the critical proteins in tumor metastasis and decreased in bisphosphonate-treated PC-3 cells. Diphosphonates plasminogen activator, urokinase Homo sapiens
2 Urokinase-type plasminogen activator (uPA) is one of the critical proteins in tumor metastasis and decreased in bisphosphonate-treated PC-3 cells. Diphosphonates plasminogen activator, urokinase Homo sapiens
3 We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition. Diphosphonates plasminogen activator, urokinase Homo sapiens
4 We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition. Diphosphonates plasminogen activator, urokinase Homo sapiens