Title : Tetrandrine prevents acquired drug resistance of K562 cells through inhibition of mdr1 gene transcription.

Pub. Date : 2010 May

PMID : 19898868






2 Functional Relationships(s)
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1 However, tetrandrine could markedly inhibit the doxorubicin-induced expression of NF-kappaB mRNA and protein. tetrandrine nuclear factor kappa B subunit 1 Homo sapiens
2 CONCLUSION: In summary, tetrandrine can prevent doxorubicin-induced mdr1 mRNA/P-gp expression and P-gp functions in a dose-dependent manner through a mechanism that may involve inhibition of doxorubicin-induced NF-kappaB mRNA expression and protein activity. tetrandrine nuclear factor kappa B subunit 1 Homo sapiens