Title : c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?

Pub. Date : 2009 Jan 1

PMID : 19898681






1 Functional Relationships(s)
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1 After a noxious stimulus (e.g., capsaicin injection) or tissue injury, c-Fos begins to be induced after 30-60 minutes, whereas pERK can be induced within a minute, which can correlate well with the development of pain hypersensitivity. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus