Title : Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.

Pub. Date : 2009 Nov 20

PMID : 19896393






1 Functional Relationships(s)
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1 Sustained production of PI(3,4,5)P(3) in B cells, achieved through conditional deletion of Pten, resulted in failed tolerance induction and abundant autoantibody production. phosphoinositide-3,4,5-triphosphate phosphatase and tensin homolog Homo sapiens