Title : Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.

Pub. Date : 2009 Dec 25

PMID : 19880517






1 Functional Relationships(s)
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1 Thus, Asn(140) does not contribute substantially to substrate binding but is essential for the chemical step, where it stabilizes the transition state by approximately 6 kcal/mol (compared with 11.6 kcal/mol stabilization provided by TDG overall). Asparagine thymine DNA glycosylase Homo sapiens