Pub. Date : 2009 Nov 1
PMID : 19861538
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show a mechanism through which BRAF induces NIS repression and promotes epithelial to mesenchimal transition and invasion based on the operation of an autocrine transforming growth factor (TGF)beta loop. | Nickel | transforming growth factor beta 1 | Homo sapiens |
| 2 | BRAF induces secretion of functional TGFbeta and blocking TGFbeta/Smad signaling at multiple levels rescues BRAF-induced NIS repression. | Nickel | transforming growth factor beta 1 | Homo sapiens |
| 3 | BRAF induces secretion of functional TGFbeta and blocking TGFbeta/Smad signaling at multiple levels rescues BRAF-induced NIS repression. | Nickel | transforming growth factor beta 1 | Homo sapiens |
| 4 | Interestingly, TGFbeta is overexpressed in the invasive front, whereas NIS is preferentially expressed in the central regions of the tumors, suggesting that this negative correlation between TGFbeta and NIS occurs locally inside the tumor. | Nickel | transforming growth factor beta 1 | Homo sapiens |
| 5 | Our study describes a novel mechanism of NIS repression in thyroid cancer and provides evidence that TGFbeta may play a key role in promoting radioiodide resistance and tumor invasion during PTC progression. | Nickel | transforming growth factor beta 1 | Homo sapiens |