Pub. Date : 1991 Jan 15
PMID : 1985950
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Experimental evidence indicates that the purified nonactivated glucocorticoid receptor contains a single steroid-binding protein and two approximately 90-kDa nonsteroid-binding subunits identified as heat shock protein (hsp) 90. | Steroids | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
2 | The cell-free synthesized glucocorticoid receptor is able to bind steroid and can be activated further to the DNA-binding form. | Steroids | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
3 | To test the hypothesis of an active role played by hsp90 in the stabilization of a competent steroid-binding conformation of the glucocorticoid receptor, we have synthesized the receptor in a reticulocyte lysate that has been depleted of hsp90 by immunoadsorption with AC88 anti-hsp90. | Steroids | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |