Title : Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.

Pub. Date : 2009 Dec 18

PMID : 19858202






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In human primary and Jurkat T lymphocytes, activation of CB1 by R(+)-methanandamide, CB2 by JWH015, and both by Delta9-tetrahydrocannabinol induced a short decrease in cyclic AMP lasting less than 1 h. However, this decrease was followed by a massive (up to 10-fold) and sustained (at least up to 48 h) increase in cyclic AMP. JHW 015 cannabinoid receptor 1 Homo sapiens