Title : Restoration of the DNA binding activity of estrogen receptor in MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.

Pub. Date : 1991 Jan

PMID : 1984779






4 Functional Relationships(s)
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1 Treatment with 1% DFMO was associated with an increase in uterine estrogen receptor DNA binding (1,100 +/- 218 fmoles/mg of DNA) in MRL-lpr/lpr mice (P less than 0.001). Eflornithine Fas (TNF receptor superfamily member 6) Mus musculus
2 Treatment with 1% DFMO was associated with an increase in uterine estrogen receptor DNA binding (1,100 +/- 218 fmoles/mg of DNA) in MRL-lpr/lpr mice (P less than 0.001). Eflornithine Fas (TNF receptor superfamily member 6) Mus musculus
3 Polyamine levels were 2-6-fold higher in the uterine tissues of untreated MRL-lpr/lpr mice compared with the BALB/c mice and were significantly reduced by DFMO treatment. Eflornithine Fas (TNF receptor superfamily member 6) Mus musculus
4 Polyamine levels were 2-6-fold higher in the uterine tissues of untreated MRL-lpr/lpr mice compared with the BALB/c mice and were significantly reduced by DFMO treatment. Eflornithine Fas (TNF receptor superfamily member 6) Mus musculus