Pub. Date : 2009 Nov
PMID : 19845434
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 2 | Mechanism-based inhibition of CYP2C19 in human liver microsomes by the thienopyridine antiplatelet agents clopidogrel, prasugrel and their thiolactone metabolites was investigated by determining the time- and concentration-dependent inhibition of the activity of S-mephenytoin 4"-hydroxylase as typical CYP2C19 activity and compared with ticlopidine and its metabolite. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 3 | Clopidogrel was shown to be a mechanism-based inhibitor of CYP2C19 with the inactivation kinetic parameters, k(inact) and K(I), equal to 0.0557 min(-1) and 14.3 microM, respectively, as well as ticlopidine (0.0739 min(-1) and 3.32 microM, respectively). | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 4 | The thiolactone metabolite of ticlopidine and clopidogrel inhibited CYP2C19 only in a concentration-dependent manner. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |