Title : Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid.

Pub. Date : 2010 Jan

PMID : 19818404






3 Functional Relationships(s)
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1 We tested our hypothesis that PFOA interferes with Leydig cell steroidogenic enzymes by measuring its effect on 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase 3 (17beta-HSD3) activities in rat testis microsomes and Leydig cells. 3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid hydroxysteroid (17-beta) dehydrogenase 3 Rattus norvegicus
2 We tested our hypothesis that PFOA interferes with Leydig cell steroidogenic enzymes by measuring its effect on 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase 3 (17beta-HSD3) activities in rat testis microsomes and Leydig cells. 3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid hydroxysteroid (17-beta) dehydrogenase 3 Rattus norvegicus
3 In conclusion, PFOA inhibits 3beta-HSD and 17beta-HSD3 in rat Leydig cells. 3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid hydroxysteroid (17-beta) dehydrogenase 3 Rattus norvegicus