Pub. Date : 2010 Jan 15
PMID : 19818386
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-alpha. | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 2 | This study examines whether TNF-alpha modulates the capsaicin-induced effects after transient receptor potential vanilloid (TRPV)-1 receptor activation on voltage activated calcium channel currents (I(Ca(V))). | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 3 | Eliciting I(Ca(V)) in DRG neurons of rats by a depolarization from the resting potential to 0 mV, TNF-alpha (100 ng/ml) reduces I(Ca(V)) by 16.9+/-2.2%, while capsaicin (0.1 microM) decreases currents by 27+/-4.3%. | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 4 | Pre-application of TNF-alpha (100 ng/ml) for 24h results in a sensitization of I(Ca(V)) to capsaicin (0.1 microM) with a reduction of 42.8+/-4.4% mediated by TRPV-1. | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 5 | Summarizing, TNF-alpha sensitizes nociceptive neurons for capsaicin. | Capsaicin | tumor necrosis factor | Rattus norvegicus |