Title : Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.

Pub. Date : 2010 Jan

PMID : 19812348






1 Functional Relationships(s)
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1 These studies showed that CYP2C19 contributed substantially to both oxidative steps required in the formation of clopidogrel active metabolite and that CYP3A4 contributed substantially to the second oxidative step. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens