Title : Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat.

Pub. Date : 2010 May

PMID : 19800272






3 Functional Relationships(s)
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1 Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat. resiniferatoxin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 In conclusion, using measurement of threshold temperatures eliciting nocifensive reactions in rats both in the hot and cold range revealed that capsaicin and RTX impair thermosensation in both noxious ranges due to a functional desensitization of peripheral terminals of TRPV1-expressing sensory neurons responsible for noxious heat and cold responsiveness. resiniferatoxin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
3 This could be differentiated from desensitization of TRPV1 receptor evoked by lower doses of resiniferatoxin or N-oleoyldopamine. resiniferatoxin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus