Title : Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan.

Pub. Date : 2010 Jan

PMID : 19797609






2 Functional Relationships(s)
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1 The metabolite identification revealed that CYP3A4 catalyzed the formation of a variety of metabolites as a result of presenting different parts of the substrates to the heme. Heme cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Levallorphan acted as a time-dependent inhibitor on CYP3A4, indicating a productive binding mode with this enzyme not observed with CYP2D6 that presumably resulted from close interactions of the N-allyl moiety oriented toward the heme. Heme cytochrome P450 family 3 subfamily A member 4 Homo sapiens