Pub. Date : 2010
PMID : 19786805
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhaled budesonide increased TIMP-1 levels in both groups of asthmatic children and normalized the MMP-8/TIMP-1 ratio, and this paralleled the improvement in forced expiratory volume in 1 s in children with mild symptoms. | Budesonide | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 2 | Inhaled budesonide increased TIMP-1 levels in both groups of asthmatic children and normalized the MMP-8/TIMP-1 ratio, and this paralleled the improvement in forced expiratory volume in 1 s in children with mild symptoms. | Budesonide | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 3 | Budesonide decreased the percentage of MMP-8-positive macrophages and increased that of TIMP-1-positive macrophages; these changes were significant in asthmatic children with mild symptoms. | Budesonide | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 4 | CONCLUSIONS: Inhaled budesonide normalized the MMP-8/TIMP-1 ratio in asthmatic children by upregulation of TIMP-1 production and downregulation of MMP-8 production by airway macrophages. | Budesonide | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 5 | CONCLUSIONS: Inhaled budesonide normalized the MMP-8/TIMP-1 ratio in asthmatic children by upregulation of TIMP-1 production and downregulation of MMP-8 production by airway macrophages. | Budesonide | TIMP metallopeptidase inhibitor 1 | Homo sapiens |