Pub. Date : 2010 Mar
PMID : 19786087
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Combined treatment with esculetin and HA14-1 upregulated the expression of death receptor 4 (DR4), and activation of extracellular-regulated kinase (ERK) in a time-dependent manner. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Combined treatment with esculetin and HA14-1 upregulated the expression of death receptor 4 (DR4), and activation of extracellular-regulated kinase (ERK) in a time-dependent manner. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | In addition, esculetin and HA14-1-mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression, suggesting that the synergistic effect was at least partially mediated through ERK-dependent induction of DR4 expression. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | In addition, esculetin and HA14-1-mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression, suggesting that the synergistic effect was at least partially mediated through ERK-dependent induction of DR4 expression. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | The results indicate that HA14-1-induced reversal of the anti-apoptotic effect of Bcl-2 confers apoptosis sensitivity to esculetin by a mitochondrial amplification step and through the ERK-dependent induction of DR4 expression in U937/Bcl-2 cells. | esculetin | mitogen-activated protein kinase 1 | Homo sapiens |