Title : High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886).

Pub. Date : 2009 Nov

PMID : 19783898






1 Functional Relationships(s)
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1 Subsequent molecular characterization showed that treatment with AZD6244 suppressed ERK phosphorylation in both sensitive and resistant cells, suggesting that resistance is not mediated by the activities of MEK/ERK themselves. AZD 6244 mitogen-activated protein kinase 1 Homo sapiens