Pub. Date : 2009 Dec
PMID : 19781786
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS. | Hyaluronic Acid | toll-like receptor 4 | Mus musculus |
| 2 | Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with CD44. | Hyaluronic Acid | toll-like receptor 4 | Mus musculus |
| 3 | Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters lipopolysaccharide (LPS) responsiveness and thus could alter the septic response. | Hyaluronic Acid | toll-like receptor 4 | Mus musculus |
| 4 | Investigation of the mechanism responsible for inhibition of LPS activation showed hyaluronan treatment resulted in an increase in peritoneal macrophage A20 mRNA expression, and that this was significantly reduced in macrophages from Cd44(-/-) mice and Tlr4(-/-) mice. | Hyaluronic Acid | toll-like receptor 4 | Mus musculus |
| 5 | Therefore, our results show that hyaluronan acts through TLR4, CD44 and A20 to stimulate a unique cellular response that can protect against the septic response to LPS. | Hyaluronic Acid | toll-like receptor 4 | Mus musculus |