Title : Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes.

Pub. Date : 2010 Jan 5

PMID : 19781537






3 Functional Relationships(s)
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1 We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1. Arsenic Trioxide cyclin dependent kinase 1 Homo sapiens
2 We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1. Arsenic Trioxide cyclin dependent kinase 1 Homo sapiens
3 We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1. Arsenic Trioxide cyclin dependent kinase 1 Homo sapiens