Pub. Date : 2009 Sep 24
PMID : 19775474
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Testosterone induced ERK and Akt phosphorylation, which could be abrogated by ER-alpha 36 shRNA knockdown or the kinase inhibitors, U0126 and LY294002, and the aromatase inhibitor letrozole. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSION: Testosterone induces ERK and Akt phosphorylation via the membrane-initiated signaling pathways mediated by ER-alpha36, suggesting a possible involvement of ER-alpha 36 in testosterone carcinogenesis. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |