Pub. Date : 2010 Jan
PMID : 19766691
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | These effects of curcumin are dose dependent and correlate with the suppression of MCP-1 mRNA expression levels. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | Therefore, one possible anti-inflammatory mechanism of curcumin may be to inhibit the secretions of inflammatory MCP-1 chemokine. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |