Title : Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase.

Pub. Date : 2009 Nov 11

PMID : 19754428






1 Functional Relationships(s)
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1 The location of the NAG site is identical to that of the weak bacterial CPS activator IMP (inosine monophosphate) in Escherichia coli CPS, indicating a common origin for these sites and excluding any relatedness to the binding site of the other bacterial CPS activator, ornithine. Inosine Monophosphate N-acetyl-alpha-glucosaminidase Homo sapiens