Pub. Date : 2009 Oct
PMID : 19744012
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients. | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | BACKGROUND AND OBJECTIVE: Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | BACKGROUND AND OBJECTIVE: Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | The present study aimed to assess the effect of the CYP3A5*3 genotype on serum concentration of CBZ at the steady-state in Korean epileptic patients. | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | Dose-normalized concentrations (mean +/- SD) of CBZ were 9.9 +/- 3.4 ng/mL/mg for CYP3A5 expressors and 13.1 +/- 4.5 ng/mL/mg for CYP3A5 non-expressors (P = 0.032). | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 6 | Dose-normalized concentrations (mean +/- SD) of CBZ were 9.9 +/- 3.4 ng/mL/mg for CYP3A5 expressors and 13.1 +/- 4.5 ng/mL/mg for CYP3A5 non-expressors (P = 0.032). | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 7 | The oral clearance of CBZ was significantly higher in CYP3A5 non-expressors than that of CYP3A5 expressors (0.056 +/-0.017 L/h/kg vs. 0.040 +/- 0.014 L/h/kg, P = 0.004). | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 8 | The CYP3A5 genotype affected the CBZ concentrations in Korean epileptic patients and is a factor that may contribute to inter-individual variability in CBZ disposition in epileptic patients. | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 9 | The CYP3A5 genotype affected the CBZ concentrations in Korean epileptic patients and is a factor that may contribute to inter-individual variability in CBZ disposition in epileptic patients. | Carbamazepine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |