Title : C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1.

Pub. Date : 2009 Dec

PMID : 19735655






2 Functional Relationships(s)
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1 We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium (MPP(+)), and rotenone. 1-Methyl-4-phenylpyridinium insulin like growth factor 1 Homo sapiens
2 We show that a short 24-amino acid C-terminal peptide of MGF (MGF24) upregulates heme oxygenase-1 (HO-1) expression and protects SH-SY5Y cells against apoptosis and cell loss induced by three DA cell-specific neurotoxins: 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium (MPP(+)), and rotenone. 1-Methyl-4-phenylpyridinium insulin like growth factor 1 Homo sapiens