Title : Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals.

Pub. Date : 2009 Aug

PMID : 19723105






9 Functional Relationships(s)
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1 Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In HT-29 colon cancer cells, the regulation of COX-2 expression by treating with TPA (12-O-tetradecanoylphorbol-13-acetate), low-level H(2)O(2), high-level H(2)O(2), and finally the combinations of TPA and low H(2)O(2) or high H(2)O(2) was investigated. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
3 In HT-29 colon cancer cells, the regulation of COX-2 expression by treating with TPA (12-O-tetradecanoylphorbol-13-acetate), low-level H(2)O(2), high-level H(2)O(2), and finally the combinations of TPA and low H(2)O(2) or high H(2)O(2) was investigated. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
4 In HT-29 colon cancer cells, the regulation of COX-2 expression by treating with TPA (12-O-tetradecanoylphorbol-13-acetate), low-level H(2)O(2), high-level H(2)O(2), and finally the combinations of TPA and low H(2)O(2) or high H(2)O(2) was investigated. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
5 We found that COX-2 expression levels with treatment reacted as follows: with TPA alone > TPA and low H(2)O(2) > low H(2)O(2) > high H(2)O(2) > TPA and high H(2)O(2). Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
6 We found that COX-2 expression levels with treatment reacted as follows: with TPA alone > TPA and low H(2)O(2) > low H(2)O(2) > high H(2)O(2) > TPA and high H(2)O(2). Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
7 We found that COX-2 expression levels with treatment reacted as follows: with TPA alone > TPA and low H(2)O(2) > low H(2)O(2) > high H(2)O(2) > TPA and high H(2)O(2). Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
8 The present findings suggest that both COX-2 stimulators (TPA and H(2)O(2)) might have differential effects on COX-2 and AMPK regulation and further apoptotic regulation. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
9 The present findings suggest that both COX-2 stimulators (TPA and H(2)O(2)) might have differential effects on COX-2 and AMPK regulation and further apoptotic regulation. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens