Title : Differential regulation of the hydrogen-peroxide-induced inhibition of gap-junction intercellular communication by resveratrol and butylated hydroxyanisole.

Pub. Date : 2009 Dec 1

PMID : 19720069






3 Functional Relationships(s)
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1 The extracellular-signal-regulated protein kinase 1/2 (ERK1/2)-connexin 43 (Cx43) signaling pathway is crucial for the regulation of GJIC in rat liver epithelial cells, and resveratrol, but not BHA, blocked the H2O2-induced phosphorylation of Cx43, a critical regulator of GJIC, and ERK1/2 in WB-F344 cells. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
2 Resveratrol appears to attenuate the H2O2-mediated ERK1/2-Cx43 signaling pathway and consequently reverses H2O2-mediated inhibition of GJIC. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
3 Resveratrol appears to attenuate the H2O2-mediated ERK1/2-Cx43 signaling pathway and consequently reverses H2O2-mediated inhibition of GJIC. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus