Pub. Date : 2009 Aug 28
PMID : 19714254
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | These insects have two AChE genes (AP and AO), and only AP-AChE carries the Cys residue. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Recently we reported a Cys-targeting small molecule that irreversibly inhibited all AChE activity extracted from aphids while an identical exposure caused no effect on the human AChE. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Full inhibition of AChE in aphids indicates that AP-AChE contributes most of the enzymatic activity and suggests that the Cys residue might serve as a target for developing better aphicides. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | Full inhibition of AChE in aphids indicates that AP-AChE contributes most of the enzymatic activity and suggests that the Cys residue might serve as a target for developing better aphicides. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 8 | This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |