Pub. Date : 2009 Sep-Oct
PMID : 19708687
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital on gene transcription. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital on gene transcription. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | Interestingly, in primary cultures of hepatocytes isolated from CAR/PXR(-/-) knockout mice, phenobarbital increased HNF-4alpha levels. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | In further experiments in these hepatocyte cultures we provide evidence that phenobarbital directly induces transcription of the PPARalpha gene via its HNF-4alpha response element, and indirectly by lack of inhibitory crosstalk of AMPK, CAR and PXR with HNF-4alpha. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | Our results provide further insight into CAR and PXR-independent effects of phenobarbital and the crosstalk between different nuclear receptor signaling pathways. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |