Title : Protein interactions involving the gamma2 large cytoplasmic loop of GABA(A) receptors modulate conductance.

Pub. Date : 2009 Dec

PMID : 19703932






2 Functional Relationships(s)
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1 Diazepam increases the conductance of some of these native channels but never those of recombinant receptors, unless they are coexpressed with GABARAP. Diazepam GABA type A receptor-associated protein Homo sapiens
2 Here we report that when applied to inside-out patches, a peptide mimicking the MA helix of the gamma2 subunit (gamma(381-403)) of the GABA(A) receptor abrogates the potentiating effect of diazepam on both endogenous receptors and recombinant GABA(A) receptors coexpressed with GABARAP, by substantially reducing their conductance. Diazepam GABA type A receptor-associated protein Homo sapiens