Pub. Date : 2009 Aug
PMID : 19702548
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study demonstrated that in addition to CYP3A4 and CYP2D6, the metabolism of loratadine is also catalyzed by CYP1A1, CYP2C19, and to a lesser extent by CYP1A2, CYP2B6, CYP2C8, CYP2C9 and CYP3A5. | Loratadine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | High inter-subject variability in loratadine steady-state data is probably due to the phenotypical characteristics of CYP2D6, CYP2C19, and CYP3A4. | Loratadine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The relative abundance of CYP3A4 in the human liver exceeds that of CYP2C19 and CYP2D6 and therefore the contribution of CYP3A4 in the metabolism of loratadine should be major (approximately 70%). | Loratadine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The relative abundance of CYP3A4 in the human liver exceeds that of CYP2C19 and CYP2D6 and therefore the contribution of CYP3A4 in the metabolism of loratadine should be major (approximately 70%). | Loratadine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |