Title : Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.

Pub. Date : 2009 Sep 15

PMID : 19692250






2 Functional Relationships(s)
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1 The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC(50) of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC(50)=12 nM, 389-fold). Isoflavones acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC(50) of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC(50)=12 nM, 389-fold). Isoflavones acetylcholinesterase (Cartwright blood group) Homo sapiens