Title : HMGA1 levels influence mitochondrial function and mitochondrial DNA repair efficiency.

Pub. Date : 2009 Oct

PMID : 19687300






3 Functional Relationships(s)
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1 Additionally, the level of cellular reactive oxygen species (ROS) increased and the efficiency of repair of oxidatively damaged mtDNA decreased as consequences of elevated HMGA1 expression. Reactive Oxygen Species high mobility group AT-hook 1 Homo sapiens
2 Additionally, the level of cellular reactive oxygen species (ROS) increased and the efficiency of repair of oxidatively damaged mtDNA decreased as consequences of elevated HMGA1 expression. Reactive Oxygen Species high mobility group AT-hook 1 Homo sapiens
3 Increased ROS levels and reduced repair efficiency in HMGA1-overexpressing cells likely contribute to the increased occurrence of mutations in mtDNA frequently observed in cancer cells. Reactive Oxygen Species high mobility group AT-hook 1 Homo sapiens