Title : Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients.

Pub. Date : 2010 Jun

PMID : 19682085






4 Functional Relationships(s)
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1 The aim of this study is to explore in patients with kidney transplantation whether AZA-related side effects can be explained by the inosine triphophate pyrophosphatase (ITPA) or thiopurine S-methyltransferase (TPMT) polymorphisms using both pheno-and genotyping. Azathioprine inosine triphosphatase Homo sapiens
2 The aim of this study is to explore in patients with kidney transplantation whether AZA-related side effects can be explained by the inosine triphophate pyrophosphatase (ITPA) or thiopurine S-methyltransferase (TPMT) polymorphisms using both pheno-and genotyping. Azathioprine inosine triphosphatase Homo sapiens
3 Patients with ITPA 94C>A homozygous allele are at high risk to develop AZA-related gastrointestinal toxicity and flu-like symptoms (P < 0.01). Azathioprine inosine triphosphatase Homo sapiens
4 TPMT wild-type/ITPA variant (homozygote) is closely related to the AZA-induced side effects (P < 0.01). Azathioprine inosine triphosphatase Homo sapiens