Title : The crystal structure of the C-terminus of adseverin reveals the actin-binding interface.

Pub. Date : 2009 Aug 18

PMID : 19666531






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Adseverin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Calcium gelsolin Homo sapiens
2 This structure is highly similar to that of the activated form of the C-terminal half of gelsolin (G4-G6), both in arrangement of domains and in the 3 bound calcium ions. Calcium gelsolin Homo sapiens
3 A model of calcium-free adseverin, constructed from the structure of gelsolin, predicts that in the absence of a gelsolin-like C-terminal extension the interaction between A2 and A6 provides the steric inhibition to prevent interaction with F-actin. Calcium gelsolin Homo sapiens