Pub. Date : 2009 Dec
PMID : 19666112
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR. | Sirolimus | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | We found that rapamycin induces the TGFbeta/Smad signaling cascade in rat mesangial cells (MC) as depicted by the nuclear translocation of phospho-Smads 2, -3 and Smad-4, respectively. | Sirolimus | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | In conclusion, activation of the profibrotic TGFbeta/Smad signaling cascade accompanies the immunosuppressive and antiproliferative actions of rapamycin. | Sirolimus | transforming growth factor, beta 1 | Rattus norvegicus |