Title : Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.

Pub. Date : 2009 Dec

PMID : 19666112






3 Functional Relationships(s)
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1 Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR. Sirolimus transforming growth factor, beta 1 Rattus norvegicus
2 We found that rapamycin induces the TGFbeta/Smad signaling cascade in rat mesangial cells (MC) as depicted by the nuclear translocation of phospho-Smads 2, -3 and Smad-4, respectively. Sirolimus transforming growth factor, beta 1 Rattus norvegicus
3 In conclusion, activation of the profibrotic TGFbeta/Smad signaling cascade accompanies the immunosuppressive and antiproliferative actions of rapamycin. Sirolimus transforming growth factor, beta 1 Rattus norvegicus