Title : CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.

Pub. Date : 2009 Oct 29

PMID : 19666078






2 Functional Relationships(s)
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1 In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated. genkwanin cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 The metabolism of genkwanin to apigenin and of chrysin to baicalein was favored by CYP1B1 and CYP1A1, respectively. genkwanin cytochrome P450 family 1 subfamily A member 1 Homo sapiens