Title : Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock.

Pub. Date : 2009 Oct

PMID : 19665733






2 Functional Relationships(s)
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1 This study investigated whether VPA treatment works through the c-Jun N-terminal kinase (JNK)/Caspase-3 survival pathways. Valproic Acid caspase 3 Rattus norvegicus
2 Treatment with VPA decreased the phospho-JNK (P=0.06) expression at 24h, without changing the total levels of JNK (P=0.89), and this correlated with attenuation of activated caspase-3 at 24h (P=0.04), compared with the non-resuscitated animals. Valproic Acid caspase 3 Rattus norvegicus