Title : Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways.

Pub. Date : 2009 Oct 9

PMID : 19664603






3 Functional Relationships(s)
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1 Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways. Lycopene AKT serine/threonine kinase 1 Homo sapiens
2 Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation. Lycopene AKT serine/threonine kinase 1 Homo sapiens
3 Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation. Lycopene AKT serine/threonine kinase 1 Homo sapiens